FEATURES

DESCRIPTION

Also known as LMAN1_HUMAN, LMAN1, ERGIC53, F5F8D. Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Exists both as a covalent disulfide-linked homohexamer, and a complex of three disulfide-linked dimers non-covalently kept together. Interacts with MCFD2. May interact with TMEM115. Interacts with RAB3GAP1 and RAB3GAP2 (PubMed:22337587). Interacts with UBXN6 (PubMed:22337587).

Also known as LMAN1_HUMAN, LMAN1, ERGIC53, F5F8D. Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

LMAN1

Protein ERGIC-53

LMAN1

Molecular Synopsis