FEATURES

FAMILY

DESCRIPTION

Also known as DHYS_HUMAN, DHPS, DS. Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue (PubMed:30661771). This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. Homotetramer formed by a dimer of dimers.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DHPS

Deoxyhypusine synthase

DHPS

Molecular Synopsis