FEATURES

FAMILY

DESCRIPTION

Also known as CLK1_HUMAN, CLK1, CLK. Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA. Interacts with PPIG and UBL5.

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EXTERNAL LINKS

CLK1

Dual specificity protein kinase CLK1

ligandability Mutations

CLK1

Molecular Synopsis