FEATURES

FAMILY

Fatty-acid binding protein (FABP) family

DESCRIPTION

Also known as FABP6_HUMAN, FABP6, ILBP, ILLBP. Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity)., Essential for the survival of colon cancer cells to bile acid-induced apoptosis.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FABP6

Mutations

Mutation(s) distribution

Mutations table