FEATURES

FAMILY

DESCRIPTION

Also known as CLCN2_HUMAN, CLCN2. Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (PubMed:29403011, PubMed:29403012).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CLCN2

Chloride channel protein 2

CLCN2

Molecular Synopsis