FEATURES

FAMILY

DESCRIPTION

Also known as NR0B1_HUMAN, NR0B1, AHC, DAX1. Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Homodimer. Interacts with NR5A1, NR5A2, NR0B2 and with COPS2. Interacts with ESRRB; represses ESRRB activity at the GATA6 promoter (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NR0B1

Nuclear receptor subfamily 0 group B member 1

NR0B1

Molecular Synopsis