FEATURES

FAMILY

DESCRIPTION

Also known as AK1D1_HUMAN, AKR1D1, SRD5B1. Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

AKR1D1

Aldo-keto reductase family 1 member D1

Mutations

Mutation(s) distribution

Mutations table

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