FEATURES

DESCRIPTION

Also known as GDS1_HUMAN, RAP1GDS1. Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein (PubMed:1549351, PubMed:11948427). Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake (PubMed:24349085). Interacts with RABL3.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RAP1GDS1

Rap1 GTPase-GDP dissociation stimulator 1

Mutations

Mutation(s) distribution

Mutations table

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