FEATURES

FAMILY

DESCRIPTION

Also known as KIF11_HUMAN, KIF11, EG5, KNSL1, TRIP5. Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Interacts (via C-terminus) with the kinase NEK6 in both interphase and mitosis. Interacts with RARRES1 and AGBL2 (PubMed:21303978).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

KIF11

Mutations

Mutation(s) distribution

Mutations table