FEATURES

FAMILY

DESCRIPTION

Also known as VPS4_YEAST, VPS4, CSC1, DID6, END13, GRD13, VPL4, VPT10. Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex. Monomer or homodimer (in nucleotide-free form). Decamer, dodecamer or tetradecamer of two stacked respective homooligomeric rings (when bound to ATP); the dodecameric form seems to be predominant. Interacts with VPS20. Interacts with VTA1; the interaction requires the dimeric structure of VTA1; 6 homodimers of VTA1 appear to associate with the dodecameric VSP4 complex. Interacts with DID2. Interacts with DID4. Interacts with IST1; IST1 competes with VTA1 for binding with VPS4.

Also known as VPS4_YEAST, VPS4, CSC1, DID6, END13, GRD13, VPL4, VPT10. Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Req ...

EXTERNAL LINKS

VPS4

Mutations

Mutation(s) distribution

Mutations table