FEATURES

DESCRIPTION

Also known as VID30_YEAST, VID30, GID1. Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:9737955, PubMed:12686616). Required for proteasome-dependent catabolite degradation of fructose-1, 6-bisphosphatase (FBP1) (PubMed:9737955, PubMed:12686616, PubMed:22645139, PubMed:28126757). Identified in the GID complex. In the absence of glucose, the complex contains VID30/GID1, the E3 ubiquitin-ligase RMD5/GID2, VID28/GID5, GID7, GID8, and FYV10/GID9. When cells are shifted to glucose-containing medium, VID24/GID4 is induced and becomes part of the complex (PubMed:22645139). Within the complex, VID30/GID1 interacts directly (via LisH domain) with GID8, and (via CTLH domain) with GID7 (PubMed:22645139).

EXTERNAL LINKS

VID30

Vacuolar import and degradation protein 30

VID30

Molecular Synopsis