FEATURES

FAMILY

DESCRIPTION

Also known as TR112_YEAST, TRM112. Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase MTQ2, required for the methylation of eRF1 on 'Gln-182'. Together with methyltransferase TRM11, required for the formation of 2-methylguanosine at position 10 (m2G10) in tRNA. Together with methyltransferase BUD23, required for the formation of 7-methylguanine at position 1575 (m7G1575) in 18S rRNA. Involved in biogenesis of both 40S and 60S ribosomal subunits. Heterodimer of MTQ2-TRM112, forming the eRF1 methyltransferase. TRM112 is necessary for the solubility and activity of the catalytic subunit MTQ2. Interacts with TRM11; required for full tRNA methyltransferase activity. Interacts with BUD23; required for full rRNA methyltransferase activity. Interacts with RCM1, NOP2, TRM9 and LYS9.

EXTERNAL LINKS

TRM112

Mutations

Mutation(s) distribution

Mutations table