FEATURES

FAMILY

DESCRIPTION

Also known as IF5_HUMAN, EIF5. Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). Interacts with FMR1 isoform 6; this interaction occurs in a RNA-dependent manner.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

EIF5

Eukaryotic translation initiation factor 5

EIF5

Molecular Synopsis