FEATURES

FAMILY

Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family

DESCRIPTION

Also known as ADIC_ECO57, adiC. Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach (Probable). Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular protons (PubMed:19478139, PubMed:25136114). Probably undergoes several conformational states in order to translocate the substrate across the membrane; keeps the substrate accessible to only 1 side of the membrane at a time by opening and closing 3 membrane-internal gates (Probable). Homodimer;each subunit has its own individual transport capacity.

EXTERNAL LINKS

adiC

Mutations

Mutation(s) distribution

Mutations table