FEATURES

FAMILY

DESCRIPTION

Also known as CALM_DROME, Cam. Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes (PubMed:23226104). Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance (PubMed:10480937, PubMed:29444420). Interacts with Crag (PubMed:18331716). Interacts with stac (PubMed:9813038). Interacts with Akap200; the interaction is calcium-dependent and is inhibited by PKC-mediated phosphorylation of Akap200 (PubMed:10480937).

EXTERNAL LINKS

Cam

Mutations

Mutation(s) distribution

Mutations table