FEATURES

FAMILY

DESCRIPTION

Also known as CPLX1_RAT, Cplx1. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.

EXTERNAL LINKS

uniprot
enzyme classification

Cplx1

Complexin-1

Cplx1

Molecular Synopsis