FEATURES

FAMILY

DESCRIPTION

Also known as CA1A_CONBU, CA1A. Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This peptide potently blocks numerous mammalian nAChR subtypes: alpha-6/alpha-3-beta-2 (CHRNA6/CHRNA3-CHRNB2) (IC(50)=0.258 nM) > alpha-6/alpha-3-beta-4 (CHRNA6/CHRNA3-CHRNB4) (IC(50)=1.54 nM) > alpha-3-beta-2 (CHRNA3-CHRNB2) (IC(50)=5.72 nM) > alpha-3-beta-4 (CHRNA3-CHRNB4)(IC(50)=27.7 nM) > alpha-4-beta-4 (CHRNA4-CHRNB4) (IC(50)=69.9 nM) > alpha-2-beta-4 (CHRNA2-CHRNB4) (IC(50)=121 nM) > alpha-7 (CHRNA7) (IC(50)=272 nM) > alpha-2-beta-2 (CHRNA2-CHRNB2) (IC(50)=800 nM) (PubMed:15520009). Recovery from toxin block is markedly slower for beta-4 versus beta-2 subunit-containing nAChRs (PubMed:15520009, PubMed:16964981). Residues Thr-83, Val-135 and Phe-143 in the rat beta-2 subunit and Lys-81, Ile-133 and Gln-141 in the rat beta-4 subunit are critical to off-rate differences (PubMed:16964981). Thus, this toxin represents a novel probe for distinguishing between beta-2 and beta-4 subunit-containing nAChRs (PubMed:15520009, PubMed:16964981). Also exhibits inhibition of D.melanogaster alpha-7 nAChRs (PubMed:25466886).

EXTERNAL LINKS

CA1A

Alpha-conotoxin BuIA

CA1A

Molecular Synopsis