FEATURES

FAMILY

DESCRIPTION

Also known as FA7_MOUSE, F7, Cf7. Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium (By similarity). Heterodimer of a light chain and a heavy chain linked by a disulfide bond.

EXTERNAL LINKS

uniprot
enzyme classification

F7

Mutations

Mutation(s) distribution

Mutations table