FEATURES

FAMILY

DESCRIPTION

Also known as NPD_ECOLI, cobB, ycfY. NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Activates the enzyme acetyl-CoA synthetase by deacetylating 'Lys-609' in the inactive, acetylated form of the enzyme. May also modulate the activity of other propionyl-adenosine monophosphate (AMP)-forming enzymes. Forms a 1:1 complex with acetyl-CoA synthetase (Acs).

EXTERNAL LINKS

uniprot
enzyme classification

cobB

NAD-dependent protein deacylase

cobB

Molecular Synopsis