FEATURES

DESCRIPTION

Also known as ARNA_ECOLI, arnA, pmrI, yfbG. Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Homohexamer, formed by a dimer of trimers.

EXTERNAL LINKS

uniprot
enzyme classification

arnA

Bifunctional polymyxin resistance protein ArnA

arnA

Molecular Synopsis