FEATURES

FAMILY

DESCRIPTION

Also known as IF4G2_HUMAN, EIF4G2, DAP5. Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. Interacts with the serine/threonine protein kinases MKNK1 and MKNK2. Binds EIF4A and EIF3. Interacts with MIF4GD.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

EIF4G2

Eukaryotic translation initiation factor 4 gamma 2

EIF4G2

Molecular Synopsis