FEATURES

FAMILY

DESCRIPTION

Also known as TPB_RANTE, TPB. Amphipathic alpha-helical antimicrobial peptide with potent activity against Gram-positive bacteria, weak activity against Gram-negative bacteria, and moderate activity against fungi (PubMed:9022710, PubMed:27351824, PubMed:30718667). Mainly acts by causing membrane permeabilization, but is unable to forme pore-like openings (Probable). Is also able to penetrate eukaryotic cells (keratinocytes), and kill intracellular S.aureus (both wild-type and MRSA) without injuring host cells (PubMed:24514087). Shows inhibitory effect on biofilm formation of Gram-positive bacteria, but not of Gram-negative bacteria (PubMed:27351824, PubMed:28443279). Shows antiviral activity against herpes simplex virus 1 (HSV-1) by disrupting the viral envelope (PubMed:29483113). Also displays anti-leishmania activity by damaging parasite membrane (PubMed:15513914, PubMed:25668079). Does not show hemolytic activity (PubMed:9022710, PubMed:15513914, PubMed:28443279). Acts synergistically with temporin-L that improves temporin-1Tb activity by preventing its self-association in lipopolysaccharides (LPS) (PubMed:16867990, PubMed:21586570). In vitro, promotes cell migration and wound healing (PubMed:24514087). Homo-oligomerizes in membranes as homodimers, homotrimers, or even homotetramers (Probable). Oligomerizes in presence of LPS (PubMed:16867990, PubMed:21586570). In Gram-positive bacterial mimetic membranes, the aggregation is weakly pronounced, and penetration proceeds more rapidly and is deeper than in Gram-negative bacterial mimetic membranes where aggregation is high (PubMed:30718667). Homo-oligomerization is prevented by temporin-L (PubMed:16867990, PubMed:21586570).

EXTERNAL LINKS

TPB

Temporin-1Tb

TPB

Molecular Synopsis