FEATURES

FAMILY

DESCRIPTION

Also known as GTFA_AMYOR, gtfA. Catalyzes the attachment of 4-epi-vancosamine from a TDP donor to the beta-OH-Tyr-6 of the aglycone cosubstrate in the biosynthesis of glycopeptide antibiotic chloroeremomycin, a member of the vancomycin group of antibiotics. Strongly prefers devancoaminyl-vancomycin (DVV) as substrate rather than the heptapeptide vancomycin aglycone (AGV). Acts downstream of GtfB.

EXTERNAL LINKS

uniprot
enzyme classification

gtfA

dTDP-epi-vancosaminyltransferase

gtfA

Molecular Synopsis