FEATURES

FAMILY

DESCRIPTION

Also known as FAAH1_RAT, Faah, Faah1. Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z, 8Z, 11Z, 14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:9122178, PubMed:9299394, PubMed:9790682, PubMed:10526230, PubMed:11128635, PubMed:15533037, PubMed:17649977). Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:9122178, PubMed:11128635). It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z, 8Z, 11Z, 14Z-eicosatetraenoyl)-glycerol) (PubMed:10526230, PubMed:15533037, PubMed:17649977). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity). Homodimer.

EXTERNAL LINKS

Faah

Fatty-acid amide hydrolase 1

Faah

Molecular Synopsis