FEATURES

FAMILY

anthranilate synthase component I family

DESCRIPTION

Also known as MBTI_MYCTU, mbtI, trpE2. Involved in the incorporation of salicylate into the virulence-conferring salicylate-based siderophore mycobactin. Catalyzes the initial conversion of chorismate to yield the intermediate isochorismate (isochorismate synthase activity), and the subsequent elimination of the enolpyruvyl side chain to give salicylate (isochorismate pyruvate-lyase activity). In the absence of magnesium, MbtI displays a chorismate mutase activity and converts chorismate to prephenate. Monomer.

EXTERNAL LINKS

uniprot
enzyme classification

mbtI

Mutations

Mutation(s) distribution

Mutations table