FEATURES

FAMILY

DESCRIPTION

Also known as GLYA1_MYCTU, glyA1, glyA. Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-allo-threonine. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

glyA1

Mutations

Mutation(s) distribution

Mutations table