FEATURES

FAMILY

DESCRIPTION

Also known as END8B_MYCTO, nei2, nei1. Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.

EXTERNAL LINKS

uniprot
enzyme classification

nei2

Endonuclease 8 2

nei2

Molecular Synopsis