FEATURES

DESCRIPTION

Also known as LIGD_MYCTO, ligD. With Ku forms a non-homologous end joining (NHEJ) repair enzyme which repairs DNA double-strand breaks (DSB) with reduced fidelity. Recognizes, processes and reseals DSBs, including repairs on incompatible DSB which require 3'-resection, gap filling and ligation. Anneals the 3' overhanging strands from opposing breaks to form a gapped intermediate, which then can be extended in trans by using the termini as primers for extension of the annealed break. Binds to the recessed 5'-phosphate moiety of the downstream DNA strand forming a stable synaptic complex even when the 3'-protruding ends of the template DNA strands are not complementary., The preference of the polymerase domain for rNTPs over dNTPs may be advantageous in dormant cells, where the dNTP pool is limiting. Monomer. Component of the NHEJ repair enzyme with mKu (By similarity).

EXTERNAL LINKS

ligD

Multifunctional non-homologous end joining DNA repair protein LigD

ligD

Molecular Synopsis