FEATURES

FAMILY

cysteine synthase/cystathionine beta-synthase family

DESCRIPTION

Also known as CYSM_MYCTU, cysM. Catalyzes the formation of a covalent CysO-cysteine adduct via a sulfur transfer, using the thiocarboxylated sulfur carrier protein CysO-COSH as sulfur donor and O-phospho-L-serine (OPS) as sulfur acceptor. Can also use sodium sulfide as sulfur donor in vitro, albeit with less efficiency, but not thiosulfate or thio-nitro-benzoate. O-acetylserine (OAS) is a very poor substrate in comparison with OPS. May be of particular importance for cysteine biosynthesis in the persistent phase of M.tuberculosis. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

cysM

Mutations

Mutation(s) distribution

Mutations table