FEATURES

FAMILY

DESCRIPTION

Also known as TESA_MYCTU, tesA. Involved in the synthesis of both phthiocerol dimycocerosates (PDIMs) and phenolic glycolipids (PGLs), which are structurally related lipids non-covalently bound to the outer cell wall layer of M.tuberculosis and are important virulence factors (PubMed:30292819). In vitro, TesA has both thioesterase and esterase activities (PubMed:30292819, PubMed:31388991). Exhibits thioesterase activity on acyl-CoA derivatives such as palmitoyl-CoA and decanoyl-CoA (PubMed:30292819, PubMed:31388991). Also displays hydrolytic activity on ester substrates, being more active on pNP esters with short carbon chain lengths (C2-C5) than with those bearing medium and long carbon chain lengths (C8-C18) (PubMed:30292819). Monomer. Can form homodimers in the presence of palmitoyl-CoA (PubMed:31388991). Interacts with the C-terminal region of PpsE (PubMed:15668773).

EXTERNAL LINKS

tesA

Mutations

Mutation(s) distribution

Mutations table