FEATURES

FAMILY

Siderophore-Fe(3+) uptake transporter (SIUT) (TC 3.A.1.21) family

DESCRIPTION

Also known as IRTA_MYCTU, irtA. Part of the ABC transporter complex IrtAB involved in the import of iron-bound mycobactin (Fe-MBT) and carboxymycobactin (Fe-cMBT) (PubMed:16385031, PubMed:19948799) (By similarity). Mycobactins are then reduced by the siderophore interaction domain to facilitate iron release in the bacterial cell (By similarity). Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity). Required for replication in human macrophages and in mouse lungs (PubMed:16385031). Forms a heterodimer with IrtB.

irtA

Structural Ligandability

Domains Chains

Distribution