FEATURES

FAMILY

DESCRIPTION

Also known as TMOA_PSEME, tmoA. Component of the toluene-4-monooxygenase multicomponent enzyme system which catalyzes the O2- and NADH-dependent hydroxylation of toluene to form p-cresol (PubMed:1885512, PubMed:15240250, PubMed:2019563, PubMed:19290655, PubMed:19705873). Also able to convert benzene to phenol, catechol, and 1, 2, 3-trihydroxybenzene by successive hydroxylations (PubMed:15240250). The alkene monooxygenase multicomponent enzyme system is composed of an electron transfer component and a monooxygenase component interacting with the effector protein TmoD. The electron transfer component is composed of a ferredoxin reductase (TmoF) and a ferredoxin (TmoC), and the monooxygenase component is formed by a heterohexamer (dimer of heterotrimers) of two alpha subunits (TmoA), two beta subunits (TmoE) and two gamma subunits (TmoB).

EXTERNAL LINKS

tmoA

Toluene-4-monooxygenase system, hydroxylase component subunit alpha

tmoA

Molecular Synopsis