FEATURES

FAMILY

DESCRIPTION

Also known as VPS28_YEAST, VPS28, VPT28. Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for normal endocytic and biosynthetic traffic to the yeast vacuole. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of STP22, VPS28, SRN2 and MVB12 in a 1:1:1:1 stoichiometry. Self-associates. Interacts with VPS27; the interaction mediates the association with the ESCRT-0 complex. Interacts with VPS20; the interaction mediates the association with the ESCRT-III complex.

EXTERNAL LINKS

uniprot
enzyme classification

VPS28

Vacuolar protein sorting-associated protein 28

Mutations

Mutation(s) distribution

Mutations table

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