FEATURES

FAMILY

DESCRIPTION

Also known as SLO_DROME, slo. Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Kinetics are determined by alternative splicing, phosphorylation status and its combination interaction with Slob and 14-3-3-zeta. While the interaction with Slob1 alone increases its activity, its interaction with both Slob1 and 14-3-3-zeta decreases its activity. Homotetramer; which constitutes the calcium-activated potassium channel (By similarity). Interacts with Slip1. Interacts with Slob, and, indirectly with 14-3-3-zeta via its interaction with Slob. Interacts with Pka-C1 and Src kinases, which can bind simultaneously to it.

EXTERNAL LINKS

slo

Calcium-activated potassium channel slowpoke

Mutations

Mutation(s) distribution

Mutations table

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