FEATURES

FAMILY

DESCRIPTION

Also known as FOLH1_HUMAN, FOLH1, FOLH, NAALAD1, PSM, PSMA. Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression., Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. Homodimer.

Also known as FOLH1_HUMAN, FOLH1, FOLH, NAALAD1, PSM, PSMA. Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutama ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FOLH1

Mutations

Mutation(s) distribution

Mutations table