FEATURES

FAMILY

filoviridae membrane-associated protein VP24 family

DESCRIPTION

Also known as VP24_EBOZM, VP24. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1 by interacting with the STAT1-binding region of host importins. Alternatively interacts also directly with host STAT1 and may additionally inhibit its non-phosphorylated form. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding. Interacts with host importins KPNA1, KPNA5 and KPNA6 (PubMed:17928350, PubMed:25121748, PubMed:27974555). Interacts with host STAT1 (PubMed:22383882). Interacts with host KEAP1; this interaction activates host transcription factor NRF2 by blocking its interaction with KEAP1 (PubMed:24630991).

EXTERNAL LINKS

VP24

Structural Ligandability

Domains Chains

Distribution