FEATURES

FAMILY

PA-phosphatase related phosphoesterase family

DESCRIPTION

Also known as DPP1_YEAST, DPP1, ZRG1. Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Together with LPP1, regulates intracellular DGPP and PA levels, which are phospholipid molecules believed to play a signaling role in stress response. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. Substrate preference is DGPP > LPA > PA. Activity is independent of a divalent cation ion and insensitive to inhibition by N-ethylmaleimide.

EXTERNAL LINKS

uniprot
enzyme classification

DPP1

Diacylglycerol pyrophosphate phosphatase 1

DPP1

Structural Ligandability

Domains Chains

Distribution