FEATURES

FAMILY

DESCRIPTION

Also known as VDH_STRCO, vdh. Oxidative deamination of branched-chain amino acids. Oxidizes L-valine and L-alpha-aminobutyric acid efficiently, and L-isoleucine and L-leucine less efficiently. Does not act on D-valine. The catabolism of L-valine is the major source of fatty acid precursors for macrolide biosynthesis and a vital source of antibiotic precursors. Uses NAD; no activity was found with NADP. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

vdh

Valine dehydrogenase

vdh

Structural Ligandability

Domains Chains

Distribution