lin-45 (Raf homolog serine/threonine-protein kinase)
FEATURES
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ORGANISM
Caenorhabditis elegans
FAMILY
DESCRIPTION
Also known as KRAF1_CAEEL, lin-45, raf-1. Protein kinase that participates in the induction of vulva and has roles in fertility and viability. Acts downstream of the Ras protein let-60 (PubMed:8483497, PubMed:11861555, PubMed:14724126). Required for progression of developing oocytes through the pachytene stage (PubMed:19826475). Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation (PubMed:15268855). Positively regulates lifespan upstream of mek-2 and mpk-1 (PubMed:20624915). Interacts with cdf-1 in a zinc-dependent manner which promotes its activity.
Also known as KRAF1_CAEEL, lin-45, raf-1. Protein kinase that participates in the induction of vulva and has roles in fertility and viability. Acts downstream of the Ras protein let-60 (PubMed:8483497, PubMed:11861555, PubMed:14724126). Required for progression of developing oocytes through the pachytene stage (PubMed:19826475). Plays a role in res
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lin-45

Raf homolog serine/threonine-protein kinase

Molecular Synopsis