FEATURES

FAMILY

sodium channel auxiliary subunit SCN1B (TC 8.A.17) family

DESCRIPTION

Also known as SCN1B_HUMAN, SCN1B. Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of multiple pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A., Cell adhesion molecule that plays a critical role in neuronal migration and pathfinding during brain development. Stimulates neurite outgrowth (PubMed:21994374). Has no regulatory function on the SCN2A sodium channel complex (PubMed:14622265). Component of a voltage-sensitive sodium channel complex that consists of a pore-forming alpha subunit and one or more regulatory beta subunits (PubMed:15525788, PubMed:21994374, PubMed:30190309). Interacts with SCN4A (PubMed:8125980). Interacts with NFASC. Interacts with SCN10A (By similarity). Interacts with SCN1A (PubMed:15525788, PubMed:21994374, PubMed:17928445). Interacts with SCN3A (PubMed:21994374). Interacts with SCN5A (PubMed:21994374). Interacts with SCN8A (PubMed:26900580).

EXTERNAL LINKS

SCN1B

Sodium channel subunit beta-1

SCN1B

Molecular Synopsis