FEATURES

FAMILY

DESCRIPTION

Also known as PEBB_MOUSE, Cbfb, Pebp2b, Pebpb2. Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917). Heterodimer with RUNX1, RUNX2 and RUNX3 (Probable). Interacts with COPRS. Found in a complex with PRMT5 and RUNX1 (PubMed:22193545).

Also known as PEBB_MOUSE, Cbfb, Pebp2b, Pebpb2. Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcript ...

EXTERNAL LINKS

Cbfb

Mutations

Mutation(s) distribution

Mutations table