FEATURES

FAMILY

DESCRIPTION

Also known as ALE1_YEAST, ALE1, LCA1, LPT1, SLC4. Broad specificity membrane-bound O-acyltransferase that mediates the incorporation of unsaturated acyl chains into the sn-2 position of various lysophospholipids. Preferentially acylates lysophosphocholine (LPC), but also lysophosphoethanolamine (LPE), lysophosphatidylglycerol (LPG), lysophosphatidic acid (LPA), lysophosphoethanolamine (LPE), lysophosphoinositol (LPI), and lysophosphoserine (LPS) (PubMed:17996202, PubMed:17652094, PubMed:17726007, PubMed:17675291, PubMed:17890783). Prefers an acyl residue to an alkyl residue at the sn-1 position of lysophospholipid acceptors. Accepts acyl chains in acyl-CoA from C-2 to C-20, and shows strong preference for unsaturated acyl-CoAs with 16-20 carbons (PubMed:17890783). Together with SLC1, plays a central role in phosphatidic acid (PA) biosynthesis. PA is the intermediate, from which all glycerophospholipids are synthesized (PubMed:17890783). Can also introduce an acyl chain at the sn-1 position of the lysophosphatidylcholine analog 1-hydroxy-2-hexadecyl-sn-glycero-3-phosphocholine (HHPC) (PubMed:29782033).

EXTERNAL LINKS

ALE1

Lysophospholipid acyltransferase

ALE1

Molecular Synopsis