FEATURES

DESCRIPTION

Also known as DSC1_HUMAN, DSC1, CDHF1. Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. Binds to JUP/plakoglobin.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DSC1

Desmocollin-1

DSC1

Molecular Synopsis