rnf-5 (E3 ubiquitin ligase rnf-5)
FEATURES
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ORGANISM
Caenorhabditis elegans
DESCRIPTION
Also known as RNF5_CAEEL, rnf-5. E3 ubiquitin ligase that plays a role in the maintenance of muscle cell boundaries and muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix (PubMed:15210732). Ubiquitinates the LIM domain protein unc-95, thereby regulating its dislocalization from muscle dense bodies and weakening the link between the muscle cells and the hypodermis (PubMed:20385102, PubMed:15210732). Regulation of unc-95 dissociation from muscle dense bodies by ubiquitination plays an important role in ecdysis during molting (PubMed:20385102). Plays a role in the cessation of distal tip cell migration at the end of larval morphogenesis (PubMed:22285439).
Also known as RNF5_CAEEL, rnf-5. E3 ubiquitin ligase that plays a role in the maintenance of muscle cell boundaries and muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix (PubMed:15210732). Ubiquitinates the LIM domain protein unc-95, thereby regulating its dislocalization from muscle dense bodie
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rnf-5

E3 ubiquitin ligase rnf-5

Molecular Synopsis