FEATURES

FAMILY

DESCRIPTION

Also known as TTLL4_CAEEL, ttll-4. Monoglutamylase which modifies tubulin, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins (PubMed:32747782). Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin (PubMed:32747782). Involved in side-chain glutamylation of tubulin in sensory cilia (PubMed:20519502, PubMed:27635036, PubMed:29849065). Together with ttll-5 and ttll-11, required for male mating (PubMed:27635036).

EXTERNAL LINKS

uniprot
enzyme classification

ttll-4

Tubulin polyglutamylase ttll-4

ttll-4

Molecular Synopsis