FEATURES

FAMILY

DESCRIPTION

Also known as RFAH_ECOL5, rfaH. Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains (By similarity). Also negatively controls expression and surface presentation of AG43 and possibly another AG43-independent factor that mediates cell-cell interactions and biofilm formation, . Interacts with both the nontemplate DNA and the RNA polymerase (RNAP).

rfaH

Structural Ligandability

Domains Chains

Distribution