FEATURES

FAMILY

5'-AMP-activated protein kinase gamma subunit family

DESCRIPTION

Also known as AAKG_SCHPO, cbs2. Adenine nucleotides-binding subunit gamma of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (ssp2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. AMPK is a heterotrimer of an alpha catalytic subunit (ssp2), a beta (amk2) and a gamma non-catalytic subunits (cbs2). Forms a dimer of trimers.

EXTERNAL LINKS

cbs2

Mutations

Mutation(s) distribution

Mutations table