FEATURES

FAMILY

DESCRIPTION

Also known as AHA1_YEAST, AHA1. Co-chaperone that binds to the molecular chaperone HSP82 and stimulates its ATPase activity. Binding to HSP82 promotes a conformational switch in the catalytic loop of HSP82, facilitating the interaction of the catalytic 'Arg-380' with ATP in the N-terminal nucleotide-binding domain. Although not essential, it confers thermotolerance when intracellular levels of HSP82 are limiting. Monomer. Interacts with HSP82.

EXTERNAL LINKS

uniprot
enzyme classification

AHA1

Mutations

Mutation(s) distribution

Mutations table