FEATURES

FAMILY

DESCRIPTION

Also known as M3K1_HUMAN, MAP3K1, MAPKKK1, MEKK, MEKK1. Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). Binds both upstream activators and downstream substrates in multimolecular complexes through its N-terminus (PubMed:9808624). Oligomerizes after binding MAP2K4 or TRAF2 (PubMed:9808624). Interacts with AXIN1 (PubMed:12223491, PubMed:15262978). Interacts (via the kinase catalytic domain) with STK38 (PubMed:17906693). Interacts with GRIPAP1 (PubMed:17761173).

Also known as M3K1_HUMAN, MAP3K1, MAPKKK1, MEKK, MEKK1. Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of ...

EXTERNAL LINKS

MAP3K1

Mitogen-activated protein kinase kinase kinase 1

MAP3K1

Molecular Synopsis