FEATURES

FAMILY

DESCRIPTION

Also known as NOGG_HUMAN, NOG. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed:21976273, PubMed:26643732). Homodimer. Interacts with GDF5; inhibits chondrocyte differentiation.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NOG

Noggin

NOG

Molecular Synopsis